What is the antidote for acetaminophen overdose?

Acetylcysteine is the antidote for acetaminophen overdose because it helps to replenish glutathione stores in the liver, which are depleted during an acetaminophen overdose. It works by binding to the toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), thereby preventing further liver damage. Prompt administration of acetylcysteine minimizes the risk of liver failure and other complications associated with severe acetaminophen toxicity. Its effectiveness is well-established in clinical practice, especially when administered within a certain time frame after the overdose.

Other options, while related to different medical scenarios, do not address acetaminophen toxicity: Flumazenil is used as a benzodiazepine antagonist, naloxone is effective in opioid overdoses, and glucagon is primarily used in hypoglycemic situations or for beta-blocker overdose.